JansenLab papers
Lars´ postdoc papers
Lars´ pre-PhD papers
Lars´ even earlier Papers

JansenLab papers

Sreyoshi Mitra, Dani L. Bodor, Ana F. David, João F. Mata, Beate Neumann, Sabine Reither, Christian Tischer and Lars E.T. Jansen (2019) Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin and the associated centromere complex. bioRxiv, doi:10.1101/620088

Dragan Stajic, Lília Perfeito and Lars E.T. Jansen (2019) Epigenetic gene silencing alters the mechanisms and rate of evolutionary adaptation. Nature Ecology & Evolution, 3: 491-8

Wojciech Siwek, Mariluz Gómez-Rodríguez, Daniel Sobral, Ivan R. Corrêa Jr and Lars E.T. Jansen (2018) time-ChIP: A method to determine long-term locus-specific nucleosome inheritance. Methods Mol. Biol., 1832: 131-58

Ana Stankovic, Lucie Y. Guo, João F. Mata, Dani L. Bodor, Xing-Jun Cao, Aaron O. Bailey, Jeffrey Shabanowitz, Donald F. Hunt, Benjamin A. Garcia, Ben E. Black and Lars E.T Jansen (2017) A dual inhibitory mechanism sufficient to maintain cell cycle restricted CENP-A assembly. Molecular Cell, 65: 231–246

Aimee M Deaton, Mariluz Gomez-Rodriguez, Jakub Mieczkowski, Michael Y Tolstorukov, Sharmistha Kundu, Ruslan I Sadreyev, Lars E.T. Jansen and Robert E Kingston (2016) Enhancer regions show high histone H3.3 turnover that changes during differentiation eLife, 5:e15316

Samantha J Falk, Lucie Y Guo, Nikolina Sekulic, Evan M Smoak, Tomoyasu Mani, Glennis A Logsdon, Kushol Gupta, Lars E T Jansen, Gregory D Van Duyne, Sergei A Vinogradov, Michael A Lampson and Ben E Black (2015) CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science, 348: 699-703

Dani L. Bodor, João F. Mata, Mikhail Sergeev, Ana Filipa David, Kevan J. Salimian, Tanya Panchenko, Don W. Cleveland, Ben E. Black, Jagesh V. Shah and Lars E.T. Jansen (2014) The quantitative architecture of centromeric chromatin. eLife, 2014;3:e02137

Daniele Fachinetti, H. Diego Folco, Yael Nechemia-Arbely, Luis P. Valente, Kristen Nguyen, Alex J. Wong, Quan Zhu, Andrew J. Holland, Arshad Desai, Lars E. T. Jansen and Don W. Cleveland (2013) A two-step mechanism for epigenetic specification of centromere identity and function. Nature Cell Biol., 15: 1056-66.

Dani L. Bodor and Lars E.T. Jansen (2013) How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32: 2090-2.

William C. Earnshaw et al., (2013) Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res., 21: 101-6.

Dani L. Bodor, Luis P. Valente, João F. Mata, Ben E. Black and Lars E.T. Jansen (2013) Assembly in G1 phase and Long-Term Stability are Unique Intrinsic Features of CENP-A nucleosomes. Mol. Biol. Cell., 24: 923-932

Ana Stankovic and Lars E.T. Jansen (2013) Reductionism at the vertebrate kinetochore. Journal of Cell Biology, 200: 7-8

Mariluz Gómez-Rodríguez and Lars E.T. Jansen (2013) Basic properties of epigenetic systems: lessons from the centromere. Curr Opin Genet Dev., 23: 219-27

Luis P. Valente, Mariana C.C. Silva and Lars E.T. Jansen (2012)Temporal control of epigenetic centromere specification. Chromosome Research, 20:481-92

Dani L. Bodor, Mariluz Gómez Rodríguez, Nuno Moreno and Lars E.T. Jansen (2012) Analysis of protein turnover by quantitative SNAP-based pulse-chase imaging. Current Protocols in Cell Biology, Unit 8.8.1-8.8.34, June 2012

João F. Mata, Telma Lopes, Rui Gardner and Lars E.T. Jansen (2012) A rapid FACS-based strategy to isolate human gene knockin and knockout clones. PLoS ONE, 7:e32646

Lars E.T. Jansen (2012) Sowing the seeds of centromeres. Science, 335: 299-300

Mariana C.C. Silva, Dani L. Bodor, Madison E. Stellfox, Nuno M.C. Martins, Helfrid Hochegger, Daniel R. Foltz and Lars E.T. Jansen (2012) Cdk activity couples epigenetic centromere inheritance to cell cycle progression. Developmental Cell, 22: 52-63
(Highlighed by Kaitlin M. Stimpson and Beth A. Sullivan)

Dominique Ray Gallet, Adam Woolfe, Isabelle Vassias, Céline Pellentz, Nicolas Lacoste, Aastha Puri, David C. Schultz, Nikolay A. Pchelintsev, Peter D. Adams, Lars E.T. Jansen and Geneviève Almouzni (2011) Dynamics of histone H3 deposition in vivo reveal a gap filling mechanism for H3.3 to maintain chromatin integrity. Molecular Cell, 44: 928-41

Jan H. Bergmann, Mariluz Gómez Rodríguez, Nuno M. C. Martins, Hiroshi Kimura, David A. Kelly, Hiroshi Masumoto, Vladimir Larionov, Lars E. T. Jansen and William C Earnshaw (2011) Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO Journal, 30:328-40

Ben E. Black, Lars E.T. Jansen, Daniel R. Foltz and Don W. Cleveland (2010) Centromere Identity, Function, and Epigenetic Propagation across Cell Divisions. Cold Spring Harb Symp Quant Biol, 75:403-18

Mariana C.C. Silva and Lars E.T. Jansen (2009) At the right place at the right time: Novel CENP-A binding proteins shed light on centromere assembly. Chromosoma, 118: 567-74

Christopher W. Carroll, Mariana C.C. Silva, Kristina M. Godek, Lars E.T. Jansen and Aaron F. Straight (2009) Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. Nature Cell Biol., 11, 896-902

Lars´ Postdoc Papers

Ludwig Institute for Cancer Research, La Jolla, CA

Alexander Samoshkin, Alexei Arnaoutov, Lars E. T. Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W. Cleveland and Alexander Strunnikov (2009). Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One, 4:e6831.

Daniel R. Foltz, Lars E.T. Jansen, Aaron O. Bailey, John R. Yates III, Emily A. Bassett, Stacey Wood, Ben E. Black and Don W. Cleveland (2009) Centromere-Specific Assembly of CENP-A Nucleosomes Is Mediated by HJURP. Cell, 137, 472-84

Lars E.T. Jansen, Ben E. Black, Daniel R. Foltz, and Don W. Cleveland (2007) Propagation of centromeric chromatin requires exit from mitosis. J Cell Biol., 176, 795-805
Highlighed by Christopher W. Carroll and Aaron F. Straight and Mitch Leslie.

Ben E. Black*, Lars E.T. Jansen*, Paul S. Maddox, Daniel R. Foltz, Arshad B. Desai, Jagesh V. Shah and Don W. Cleveland (2007) Centromere Identity Maintained by Nucleosomes Assembled with Histone H3 Containing the CENP-A Targeting Domain. Molecular Cell, 25, 309-22 *equal contributors

Daniel R. Foltz, Lars E.T. Jansen, Ben E. Black, Aaron O. Bailey, John R. Yates III and Don W. Cleveland (2006) The human CENP-A centromeric nucleosome-associated complex. Nature Cell Biology, 8, 458-69

Lars´ pre-PhD Papers

Leiden Institute for Chemistry, Leiden University

Masakazu Kobayashi, Francis Figaroa, Nico Meeuwenoord, Lars E.T. Jansen and Gregg Siegal (2006) Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit. J Biol Chem., 281, 4308-17

Robert C. A. M. van Waardenburg, Laurina A. de Jong, Maria A. J. van Eijndhoven, Caroline Verseyden, Dick Pluim, Lars E.T. Jansen, Mary-Ann Bjornsti, and Jan H. M. Schellens (2004) Platinated DNA Adducts Enhance Poisoning of DNA Topoisomerase I by Camptothecin. J. Biol. Chem., 279, 54502-9.

Lars E.T. Jansen, Ana I. Belo, Rinske Hulsker and Jaap Brouwer (2002) Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage. Nucleic Acids Res., 30, 3532-9.

Elies C. Woudstra, Chris Gilbert, Jane Fellows, Lars E.T. Jansen, Jaap Brouwer, Hediye Erdjument-Bromage, Paul Tempst and Jesper Q. Svejstrup (2002) A Rad26-Def1 complex co-ordinates repair and RNA polymerase II proteolysis in response to DNA damage. Nature. 415, 929-33.

Lars E.T. Jansen, Hans den Dulk, Rosalba M. Brouns, Martina de Ruijter, Jourica A. Brandsma and Jaap Brouwer (2000) Spt4 modulates Rad26 requirement in transcription-coupled nucleotide excision repair. EMBO J., 19, 6498-507.

Lars E.T. Jansen, Richard A. Verhage and Jaap Brouwer (1998) Preferential binding of yeast Rad4-Rad23 complex to damaged DNA. J Biol Chem., 273, 33111-4.

Lars´ even earlier Papers

Institute for Molecular Plant sciences, Leiden University

Annette C. Vergunst, Lars E.T. Jansen, Paul F. Fransz, J. Hans de Jong and Paul J.J. Hooykaas (2000) Cre/lox-mediated recombination in Arabidopsis: evidence for transmission of a translocation and a deletion event. Chromosoma. 109, 287-97.

Annette C. Vergunst, Lars E.T. Jansen and Paul J. Hooykaas (1998) Site-specific integration of Agrobacterium T-DNA in Arabidopsis thaliana mediated by Cre recombinase. Nucleic Acids Res., 26, 2729-34.


Our departmental web page at Biochemistry, University of Oxford
Lars is a Science Research Fellow in Biochemistry at St john´s College. We maintain an affiliation with the Insituto Gulbenkian de Ciência, Portugal

In the spotlight

Recently ...

Check out our paper in Nature Ecology & Evolution in which we report how chromatin-based heritable gene silencing in a yeast population can accelerate adaption to a novel environment. In a dramatic departure from human centromeres and mammalian transcription we explored this key question in evolution in a wonderful collaboration with Lilia Perfeito @ Gulbenkian, Portugal.

time-Chip, a novel method to determine histone inheritance

We developed new method called time-ChIP to determine histone dynamics and multi- cell cycle retention, genome wide based on SNAP pulse-chase labeling. See our recent methods paper.
we teamed up with Aimee Deaton and Bob Kingston (UMass) to apply this novel technique to understand how histone dynamics contributes to gene regulation in mouse ES cells and during differentiation. Have a look at our paper in eLife.

CENP-A assembly kept in check

We figured out important steps in the way that the cell cycle machinery determines when new CENP-A gets assembled at the centromere. It´s all in our 2017 Molecular Cell paper.